Cytotoxic and genotoxic effects of perfluorododecanoic acid (PFDoA) in Japanese medaka | Knowledge and Management of Aquatic Ecosystems

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Table 1

Time course numbers and frequencies of different cell alterations caused by concentrations of perfluorododecanoic acid in Japanese medaka.

Time (days)	Conc (mg/L)	Total number of cells scored	Alterations				Total number of Altered Cells	Frequency of Altered Cells (%) ±S.E

			MN	LN	FAC	B-SC
1	0.00	6513	10	14	16	20	60	0.92 ± 0.026^Aa
	0.1	6798	15	23	23	21	82	1.21 ± 0.019^Ba
	0.5	7120	14	27	30	41	112	1.57 ± 0.036^Ca
	2.5	6907	20	37	31	26	114	1.65 ± 0.025^Da
4	0.00	6645	11	12	15	23	61	0.91 ± 0.017^Aa
	0.1	7343	16	24	30	48	118	1.61 ± 0.033^Bb
	0.5	6578	28	28	29	27	112	1.70 ± 0.028^Cb
	2.5	6998	20	32	46	32	130	1.86 ± 0.018^Db
7	0.00	6809	12	13	18	19	62	0.91 ± 0.031^Aa
	0.1	6787	20	30	37	34	121	1.78 ± 0.040^Bc
	0.5	7155	20	43	42	35	140	1.96 ± 0.060^Cc
	2.5	7483	24	46	37	44	151	2.02 ± 0.023^Cc
14	0.00	6850	12	12	16	20	60	0.87 ± 0.022^Aa
	0.1	7140	34	38	31	31	134	1.88 ± 0.013^Bd
	0.5	7151	32	54	36	42	166	2.32 ± 0.018^Cd
	2.5	6583	30	54	51	42	167	2.54 ± 0.030^Dd
21	0.00	5779	12	11	24	13	60	1.04 ± 0.013^Aa
	0.1	6782	20	40	27	25	112	1.65 ± 0.028^Bb
	0.5	7540	15	33	27	48	123	1.63 ± 0.028^Cb
	2.5	6987	21	35	58	28	142	2.03 ± 0.022^Db
28	0.00	6556	13	16	23	12	64	1.02 ± 0.025^Aa
	0.1	6494	13	28	14	26	81	1.25 ± 0.035^Ba
	0.5	7633	16	23	33	42	114	1.49 ± 0.028^Ca
	2.5	6735	25	32	37	21	115	1.71 ± 0.022^Da

MN: Micronucleus; FAC: Fragmented Apoptotic Cell

B-SC: Bean-shaped cell; LN: Lobed nucleus

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